Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia

Naoya Oku; Koji Nagai; Nobuaki Shindoh; Yoh Terada; Rob W M van Soest; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1016/j.bmcl.2004.02.062

Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia

Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. doi: 10.1016/j.bmcl.2004.02.062.

Authors

Naoya Oku¹, Koji Nagai, Nobuaki Shindoh, Yoh Terada, Rob W M van Soest, Shigeki Matsunaga, Nobuhiro Fusetani

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 15109664
DOI: 10.1016/j.bmcl.2004.02.062

Abstract

Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostellettamine A (4) from a marine sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were determined by spectral and chemical methods. They inhibit histone deacetylase derived from K562 human leukemia cells with IC(50) values ranging from 17 to 80 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Cell Survival / drug effects
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology
Histone Deacetylase Inhibitors*
Humans
Inhibitory Concentration 50
K562 Cells
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Pyridinium Compounds / chemistry*
Pyridinium Compounds / isolation & purification
Pyridinium Compounds / pharmacology
Rats
Xestospongia / chemistry*

Substances

Enzyme Inhibitors
Histone Deacetylase Inhibitors
Pyridinium Compounds
cyclostellettamine G
dehydrocyclostellettamine D
dehydrocyclostellettamine E